Il tumore prostatico viene sospettato dall'urologo quando un uomo giunto in visita per sintomi legati all'ingrandimento della prostata, presenta collateralmente valori di PSA elevati o un nodulo all'esplorazione rettale. In seguito a questo sospetto, l'urologo puo' decidere di eseguire un'agobiopsia prostatica per eventualmente confermare la diagnosi.
Talvolta, tuttavia, è possibile imbattersi in una diagnosi di tumore "incidentale" all'interno del tessuto prostatico che viene rimosso durante un intervento disostruttivo eseguito per problemi di ipertrofia (e.g. TURP, HoLEP o adenomectomia prostatica).
La malattia prostatica incidentale è classificata in considerazione della percentuale di tessuto neoplastico trovato rispetto alla quantità di tessuto sano rimosso ("stadio T1a" se il tumore e' presente in meno del 5% o "stadio T1b" se il tumore interessa più del 5% del tessuto rimosso) e presenta caratteristiche biologiche e di aggressività diverse rispetto alla neoplasia diagnostica con le biopsie prostatiche ("stadio T1c").
In questi casi, la malattia prostatica è spesso meno aggressiva rispetto al tumore riscontrato con le biopsie prostatiche e risulta molto importante comprendere se la diagnosi incidentale richieda ulteriori trattamenti invasivi (e.g. chirurgia radicale, radioterapia etc.) o possa essere solamente osservata nel tempo (e.g. sorveglianza attiva). Per poter capire quale è la migliore strategia possibile, occorre prendere in considerazione e ponderare i fattori clinici e patologici che sono presenti al momento della diagnosi incidentale.
Di seguito sono riportati alcuni degli articoli scientifici pubblicati dal dr. Capitanio nell'ambito del tumore prostatico incidentale (Fonte: Pubmed-Scopus Febbraio 2023):
1: CAPITANIO U, Pfister D, Emberton M. Repeat Prostate Biopsy: Rationale,
Indications, and Strategies. Eur Urol Focus. 2015 Sep;1(2):127-136. doi:
10.1016/j.euf.2015.05.002. Epub 2015 Jun 6. PMID: 28723423.
2: Scattoni V, Russo A, Di Trapani E, CAPITANIO U, La Croce G, Montorsi F.
Repeated biopsy in the detection of prostate cancer: when and how many cores.
Arch Ital Urol Androl. 2014 Dec 30;86(4):311-3. doi: 10.4081/aiua.2014.4.311.
PMID: 25641460.
3: Stabile A, Muttin F, Zamboni S, Moschini M, Gandaglia G, Fossati N,
Dell'Oglio P, CAPITANIO U, Cucchiara V, Mazzone E, Bravi CA, Mirone V, Montorsi
F, Briganti A. Therapeutic approaches for lymph node involvement in prostate,
bladder and kidney cancer. Expert Rev Anticancer Ther. 2019 Sep;19(9):739-755.
doi: 10.1080/14737140.2019.1659135. Epub 2019 Aug 30. PMID: 31469021.
4: Scattoni V, Maccagnano C, CAPITANIO U, Gallina A, Briganti A, Montorsi F.
Random biopsy: when, how many and where to take the cores? World J Urol. 2014
Aug;32(4):859-69. doi: 10.1007/s00345-014-1335-0. Epub 2014 Jun 8. PMID:
24908067.
5: CAPITANIO U. Contemporary management of patients with T1a and T1b prostate
cancer. Curr Opin Urol. 2011 May;21(3):252-6. doi: 10.1097/MOU.0b013e328344e4ad.
PMID: 21358335.
6: CAPITANIO U, Cheng L, Lopez-Beltran A, Scarpelli M, Freschi M, Montorsi F,
Montironi R. The importance of interaction between urologists and pathologists
in incidental prostate cancer management. Eur Urol. 2011 Jul;60(1):75-7. doi:
10.1016/j.eururo.2011.03.012. Epub 2011 Mar 16. Erratum in: Eur Urol. 2012
Aug;62(2):e47. PMID: 21444149.
7: Villa L, Capogrosso P, CAPITANIO U, Martini A, Briganti A, Salonia A,
Montorsi F. Silodosin: An Update on Efficacy, Safety and Clinical Indications in
Urology. Adv Ther. 2019 Jan;36(1):1-18. doi: 10.1007/s12325-018-0854-2. Epub
2018 Dec 6. PMID: 30523608.
8: Karakiewicz PI, CAPITANIO U, Shariat S. Editorial comment on: Prostate growth
and prevalence of prostate diseases in early onset spinal cord injuries. Eur
Urol. 2009 Jul;56(1):149-50. doi: 10.1016/j.eururo.2008.01.090. Epub 2008 Feb 8.
PMID: 18280634.
9: Dell'oglio P, Valiquette AS, Leyh-Bannurah SR, Tian Z, Trudeau V, Larcher A,
Shariat SF, CAPITANIO U, Briganti A, Graefen M, Montorsi F, Karakiewicz PI.
Treatment trends and Medicare reimbursements for localized prostate cancer in
elderly patients. Can Urol Assoc J. 2018 Jul;12(7):E338-E344. doi:
10.5489/cuaj.4865. Epub 2018 Mar 19. PMID: 29603911; PMCID: PMC6118049.
10: Scattoni V, Lazzeri M, Lughezzani G, De Luca S, Passera R, Bollito E,
Randone D, Abdollah F, CAPITANIO U, Larcher A, Lista G, Gadda GM, Bini V,
Montorsi F, Guazzoni G. Head-to-head comparison of prostate health index and
urinary PCA3 for predicting cancer at initial or repeat biopsy. J Urol. 2013
Aug;190(2):496-501. doi: 10.1016/j.juro.2013.02.3184. Epub 2013 Mar 1. PMID:
23466239.
11: Salonia A, Abdollah F, CAPITANIO U, Suardi N, Gallina A, Castagna G,
Clementi MC, Briganti A, Rigatti P, Montorsi F. Circulating sex steroids and
prostate cancer: introducing the time-dependency theory. World J Urol. 2013
Apr;31(2):267-73. doi: 10.1007/s00345-012-1009-8. Epub 2013 Jan 3. PMID:
23283410.
12: CAPITANIO U, Perrotte P, Hutterer GC, Suardi N, Jeldres C, Shariat SF,
Duclos A, Arjane P, Montorsi F, Karakiewicz PI. Effect of body mass index on
prostate-specific antigen and percentage free prostate-specific antigen: results
from a prostate cancer screening cohort of 1490 men. Int J Urol. 2009
Jan;16(1):91-5. doi: 10.1111/j.1442-2042.2008.02192.x. Epub 2008 Nov 27. PMID:
19054167.
13: CAPITANIO U, Autorino R, Bandini M, Briganti A, Cheng L, Cooperberg MR, Dehò
F, Gallina A, Klotz L, Lane B, Montironi R, Salonia A, Stief C, Tombal B,
Montorsi F. Incidental Prostate Cancer (cT1a-cT1b) Is a Relevant Clinical and
Research Entity and Should Be Fully Discussed in the International Prostate
Cancer Guidelines. Eur Urol Oncol. 2021 Apr 1:S2588-9311(21)00049-3. doi:
10.1016/j.euo.2021.03.005. Epub ahead of print. PMID: 33814342.
14: Salonia A, Abdollah F, CAPITANIO U, Suardi N, Briganti A, Gallina A, Colombo
R, Ferrari M, Castagna G, Rigatti P, Montorsi F. Serum sex steroids depict a
nonlinear u-shaped association with high-risk prostate cancer at radical
prostatectomy. Clin Cancer Res. 2012 Jul 1;18(13):3648-57. doi:
10.1158/1078-0432.CCR-11-2799. Epub 2012 May 15. PMID: 22589393.
15: CAPITANIO U, Briganti A, Gallina A, Suardi N, Karakiewicz PI, Montorsi F,
Scattoni V. Predictive models before and after radical prostatectomy. Prostate.
2010 Sep 1;70(12):1371-8. doi: 10.1002/pros.21159. PMID: 20623635.
16: CAPITANIO U, Autorino R, Bandini M, Briganti A, Cheng L, Cooperberg MR, Dehò
F, Gallina A, Klotz L, Lane BR, Montironi R, Salonia A, Stief C, Tombal B,
Montorsi F. Reply to Nicolas Mottet, Olivier Rouviere, and Theodorus H. van der
Kwast. Incidental Prostate Cancer: A Real Need for Expansion in Guidelines? Eur
Urol Oncol. In press: Incidental Prostate Cancer: An Example of How Important
Guidelines Are, Especially When Evidence Is Limited. Eur Urol Oncol. 2022
Apr;5(2):261-262. doi: 10.1016/j.euo.2021.05.004. Epub 2021 Jun 1. PMID:
34083164.
17: Maccagnano C, Gallina A, Roscigno M, Raber M, CAPITANIO U, Saccà A,
Pellucchi F, Suardi N, Abdollah F, Montorsi F, Rigatti P, Scattoni V. Prostate
saturation biopsy following a first negative biopsy: state of the art. Urol Int.
2012;89(2):126-35. doi: 10.1159/000339521. Epub 2012 Jul 19. PMID: 22814003.
18: Boehm K, Dell'Oglio P, Tian Z, CAPITANIO U, Chun FKH, Tilki D, Haferkamp A,
Saad F, Montorsi F, Graefen M, Karakiewicz PI. Comorbidity and age cannot
explain variation in life expectancy associated with treatment of non-metastatic
prostate cancer. World J Urol. 2017 Jul;35(7):1031-1036. doi:
10.1007/s00345-016-1963-7. Epub 2016 Oct 28. PMID: 27796538.
19: Spahn M, Briganti A, CAPITANIO U, Kneitz B, Gontero P, Karnes JR, Schubert
M, Montorsi F, Scholz CJ, Bader P, van Poppel H, Joniau S; European Multicenter
Prostate Cancer Clinical and Translational Research Group. Outcome predictors of
radical prostatectomy followed by adjuvant androgen deprivation in patients with
clinical high risk prostate cancer and pT3 surgical margin positive disease. J
Urol. 2012 Jul;188(1):84-90. doi: 10.1016/j.juro.2012.02.2572. Epub 2012 May 12.
PMID: 22578727.
20: Jeldres C, Isbarn H, CAPITANIO U, Zini L, Bhojani N, Shariat SF, Cloutier V,
Lattouf JB, Duclos A, Jolivet-Tremblay M, Valiquette L, Saad F, Graefen M,
Montorsi F, Perrotte P, Karakiewicz PI. Development and external validation of a
highly accurate nomogram for the prediction of perioperative mortality after
transurethral resection of the prostate for benign prostatic hyperplasia. J
Urol. 2009 Aug;182(2):626-32. doi: 10.1016/j.juro.2009.04.008. Epub 2009 Jun 17.
PMID: 19535100.
21: CAPITANIO U, Scattoni V, Freschi M, Briganti A, Salonia A, Gallina A,
Colombo R, Karakiewicz PI, Rigatti P, Montorsi F. Radical prostatectomy for
incidental (stage T1a-T1b) prostate cancer: analysis of predictors for residual
disease and biochemical recurrence. Eur Urol. 2008 Jul;54(1):118-25. doi:
10.1016/j.eururo.2008.02.018. Epub 2008 Feb 26. PMID: 18314255.
22: Dell'Oglio P, Bishr M, Boehm K, Trudeau V, Larcher A, Tian Z, Sosa J,
Moschini M, Saad F, CAPITANIO U, Briganti A, Graefen M, Montorsi F, Karakiewicz
PI. Survival Outcomes in Octogenarian and Nonagenarian Patients Treated with
First-line Androgen Deprivation Therapy for Organ-confined Prostate Cancer. Eur
Urol Focus. 2018 Dec;4(6):834-841. doi: 10.1016/j.euf.2017.01.017. Epub 2017 Feb
11. PMID: 28753853.
23: Castiglione F, Benigni F, Briganti A, Salonia A, Villa L, Nini A, Di Trapani
E, CAPITANIO U, Hedlund P, Montorsi F. Naftopidil for the treatment of benign
prostate hyperplasia: a systematic review. Curr Med Res Opin. 2014
Apr;30(4):719-32. doi: 10.1185/03007995.2013.861813. Epub 2013 Dec 18. PMID:
24188134.
24: Briganti A, CAPITANIO U, Chun FK, Karakiewicz PI, Salonia A, Bianchi M,
Cestari A, Guazzoni G, Rigatti P, Montorsi F. Prediction of sexual function
after radical prostatectomy. Cancer. 2009 Jul 1;115(13 Suppl):3150-9. doi:
10.1002/cncr.24349. PMID: 19544544.
25: Briganti A, Karnes RJ, Da Pozzo LF, Cozzarini C, CAPITANIO U, Gallina A,
Suardi N, Bianchi M, Tutolo M, Salonia A, Di Muzio N, Rigatti P, Montorsi F,
Blute M. Combination of adjuvant hormonal and radiation therapy significantly
prolongs survival of patients with pT2-4 pN+ prostate cancer: results of a
matched analysis. Eur Urol. 2011 May;59(5):832-40. doi:
10.1016/j.eururo.2011.02.024. Epub 2011 Feb 22. PMID: 21354694.
26: Briganti A, CAPITANIO U, Chun FK, Gallina A, Suardi N, Salonia A, Da Pozzo
LF, Colombo R, Di Girolamo V, Bertini R, Guazzoni G, Karakiewicz PI, Montorsi F,
Rigatti P. Impact of surgical volume on the rate of lymph node metastases in
patients undergoing radical prostatectomy and extended pelvic lymph node
dissection for clinically localized prostate cancer. Eur Urol. 2008
Oct;54(4):794-802. doi: 10.1016/j.eururo.2008.05.018. Epub 2008 May 21. PMID:
18514383.
27: Ferrari M, CAPITANIO U, Rizzo N, Freschi M, Montorsi F, Rigatti P. Onset of
hydronephrosis and lower urinary tract symptoms in a previously healthy young
man: Phyllodes tumour of the prostate as a potential diagnosis. Can Urol Assoc
J. 2014 Jul;8(7-8):E561-3. doi: 10.5489/cuaj.1984. PMID: 25210565; PMCID:
PMC4137027.
28: CAPITANIO U, Suardi N, Briganti A, Gallina A, Abdollah F, Lughezzani G,
Salonia A, Freschi M, Montorsi F. Influence of obesity on tumour volume in
patients with prostate cancer. BJU Int. 2012 Mar;109(5):678-84. doi:
10.1111/j.1464-410X.2011.10453.x. Epub 2011 Jul 20. PMID: 21777363.
29: CAPITANIO U, Salonia A, Briganti A, Montorsi F. Silodosin in the management
of lower urinary tract symptoms as a result of benign prostatic hyperplasia: who
are the best candidates. Int J Clin Pract. 2013 Jun;67(6):544-51. doi:
10.1111/ijcp.12135. Epub 2013 Feb 15. PMID: 23409749.
30: Rosiello G, Pecoraro A, Deuker M, Stolzenbach LF, Martin T, Tian Z, Larcher
A, CAPITANIO U, Montorsi F, Shariat SF, Kapoor A, Saad F, Briganti A,
Karakiewicz PI. The impact of sex and age on distribution of metastases in
patients with renal cell carcinoma. Int J Clin Oncol. 2021 May;26(5):962-970.
doi: 10.1007/s10147-021-01874-3. Epub 2021 Jan 30. PMID: 33515351.
31: Sharma G, Shah M, Ahluwalia P, Dasgupta P, Challacombe BJ, Bhandari M,
Ahlawat R, Rawal S, Buffi NM, Sivaraman A, Porter JR, Rogers C, Mottrie A, Abaza
R, Rha KH, Moon D, Yuvaraja TB, Parekh DJ, CAPITANIO U, Maes KK, Porpiglia F,
Turkeri L, Gautam G. Off-clamp Versus On-clamp Robot-assisted Partial
Nephrectomy: A Propensity-matched Analysis. Eur Urol Oncol. 2023 May
14:S2588-9311(23)00081-0. doi: 10.1016/j.euo.2023.04.005. Epub ahead of print.
PMID: 37193626.
32: Pozzi E, Ventimiglia E, Fallara G, Capogrosso P, Belladelli F, Candela L,
Raffo M, Costa A, Cignoli D, Corsini C, Cazzaniga W, Boeri L, Matloob R,
CAPITANIO U, Montorsi F, Salonia A. Haemospermia in the Real- Life Setting: A
New High-Risk Stratification. Urology. 2023 Jan;171:146-151. doi:
10.1016/j.urology.2022.09.018. Epub 2022 Oct 12. PMID: 36241064.
33: Briganti A, Passoni N, Ferrari M, CAPITANIO U, Suardi N, Gallina A, Da Pozzo
LF, Picchio M, Di Girolamo V, Salonia A, Gianolli L, Messa C, Rigatti P,
Montorsi F. When to perform bone scan in patients with newly diagnosed prostate
cancer: external validation of the currently available guidelines and proposal
of a novel risk stratification tool. Eur Urol. 2010 Apr;57(4):551-8. doi:
10.1016/j.eururo.2009.12.023. Epub 2009 Dec 18. PMID: 20034730.
34: Campi R, Amparore D, CAPITANIO U, Checcucci E, Salonia A, Fiori C, Minervini
A, Briganti A, Carini M, Montorsi F, Serni S, Porpiglia F. Assessing the Burden
of Nondeferrable Major Uro-oncologic Surgery to Guide Prioritisation Strategies
During the COVID-19 Pandemic: Insights from Three Italian High-volume Referral
Centres. Eur Urol. 2020 Jul;78(1):11-15. doi: 10.1016/j.eururo.2020.03.054. Epub
2020 Apr 11. PMID: 32307215; PMCID: PMC7151319.
35: CAPITANIO U, Suardi N. Prostate cancer in 2010: GSU: misclassification or
biological progression? Nat Rev Urol. 2011 Feb;8(2):65-6. doi:
10.1038/nrurol.2010.247. PMID: 21304540.
36: CAPITANIO U, Cheng L, Lopez-Beltran A, Scarpelli M, Freschi M, Montorsi F,
Montironi R. Corrigendum to "The Importance of Interaction Between Urologists
and Pathologists in Incidental Prostate Cancer Management" [Eur Eurol
2011;60;75-7]. Eur Urol. 2012 Aug;62(2):e47. doi: 10.1016/j.eururo.2012.05.001.
Epub 2012 May 8. PMID: 27989299.
37: Bhojani N, Perrotte P, Hutterer G, Suardi N, Jeldres C, Shariat SF,
CAPITANIO U, Arjane P, Widmer H, Benard F, Peloquin F, Montorsi F, Karakiewicz
P. Body mass index and its association with genitourinary disorders in men
undergoing prostate cancer screening. J Sex Med. 2008 Sep;5(9):2141-51. doi:
10.1111/j.1743-6109.2008.00811.x. Epub 2008 Mar 19. PMID: 18355173.
38: Leyh-Bannurah SR, Zaffuto E, Dell'Oglio P, Tian Z, Moschini M, CAPITANIO U,
Briganti A, Montorsi F, Fisch M, Chun F, Kachanov M, Budäus L, Graefen M, Huland
H, Karakiewicz PI. Prediction of Complications in Radical Prostatectomy Prostate
Cancer Patients: Simulated Annealing versus Co-Morbidity Indexes. Urol Int.
2019;102(1):51-59. doi: 10.1159/000495071. Epub 2018 Nov 27. PMID: 30481764.
39: Sorce G, Hoeh B, Hohenhorst L, Panunzio A, Tappero S, Tian Z, Larcher A,
CAPITANIO U, Tilki D, Terrone C, Chun FKH, Antonelli A, Saad F, Shariat SF,
Montorsi F, Briganti A, Karakiewicz PI. Other-cause mortality and access to care
in metastatic renal cell carcinoma according to race/ethnicity. Urol Oncol. 2022
Nov;40(11):493.e9-493.e16. doi: 10.1016/j.urolonc.2022.06.022. Epub 2022 Jul 27.
PMID: 35907705.
40: Jeldres C, Suardi N, Perrotte P, CAPITANIO U, Walz J, Hutterer GC, Saad F,
Valiquette L, Graefen M, Widmer H, Karakiewicz PI. Survival after radical
prostatectomy and radiotherapy for prostate cancer: a population-based study.
Can Urol Assoc J. 2009 Feb;3(1):13-21. PMID: 19293970; PMCID: PMC2645889.
41: Rosiello G, Palumbo C, Deuker M, Stolzenbach LF, Martin T, Tian Z, Larcher
A, CAPITANIO U, Montorsi F, Shariat SF, Kapoor A, Saad F, Briganti A,
Karakiewicz PI. Partial nephrectomy in frail patients: Benefits of robot-
assisted surgery. Surg Oncol. 2021 Sep;38:101588. doi:
10.1016/j.suronc.2021.101588. Epub 2021 Apr 22. PMID: 33945961.
42: Abdollah F, Suardi N, CAPITANIO U, Gallina A, Sun M, Villa L, Scattoni V,
Bianchi M, Tutolo M, Fossati N, Karakiewicz P, Rigatti P, Montorsi F, Briganti
A. Spatial distribution of positive cores improves the selection of patients
with low-risk prostate cancer as candidates for active surveillance. BJU Int.
2013 Aug;112(4):E234-42. doi: 10.1111/bju.12152. Epub 2013 Jun 7. PMID:
23746297.
43: Villa L, CAPITANIO U, Briganti A, Abdollah F, Suardi N, Salonia A, Gallina
A, Freschi M, Russo A, Castiglione F, Bianchi M, Rigatti P, Montorsi F, Scattoni
V. The number of cores taken in patients diagnosed with a single microfocus at
initial biopsy is a major predictor of insignificant prostate cancer. J Urol.
2013 Mar;189(3):854-9. doi: 10.1016/j.juro.2012.09.100. Epub 2012 Sep 25. PMID:
23022004.
44: Dell'Oglio P, Suardi N, Boorjian SA, Fossati N, Gandaglia G, Tian Z,
Moschini M, CAPITANIO U, Karakiewicz PI, Montorsi F, Karnes RJ, Briganti A.
Predicting survival of men with recurrent prostate cancer after radical
prostatectomy. Eur J Cancer. 2016 Feb;54:27-34. doi: 10.1016/j.ejca.2015.11.004.
Epub 2015 Dec 19. PMID: 26707594.
45: Lughezzani G, Gallina A, Larcher A, Briganti A, CAPITANIO U, Suardi N, Lista
G, Abrate A, Sangalli MN, Buffi N, Cestari A, Guazzoni G, Rigatti P, Montorsi F.
Radical prostatectomy represents an effective treatment in patients with
specimen-confined high pathological Gleason score prostate cancer. BJU Int. 2013
May;111(5):723-30. doi: 10.1111/j.1464-410X.2012.11114.x. Epub 2012 Apr 4. PMID:
22487441.
46: Nocera L, Collà Ruvolo C, Stolzenbach LF, Wenzel M, Tian Z, Larcher A,
CAPITANIO U, Mirone V, Tilki D, Chun FKH, Kapoor A, Shariat SF, Saad F, Montorsi
F, Briganti A, Karakiewicz PI. Tumor Stage and Substage Predict Cancer-specific
Mortality After Nephrectomy for Nonmetastatic Renal Cancer: Histological
Subtype-specific Validation. Eur Urol Focus. 2022 Jan;8(1):182-190. doi:
10.1016/j.euf.2021.02.009. Epub 2021 Feb 27. PMID: 33653677.
47: Scattoni V, Raber M, CAPITANIO U, Abdollah F, Roscigno M, Angiolilli D,
Maccagnano C, Gallina A, Saccà A, Freschi M, Doglioni C, Rigatti P, Montorsi F.
The optimal rebiopsy prostatic scheme depends on patient clinical
characteristics: results of a recursive partitioning analysis based on a 24-core
systematic scheme. Eur Urol. 2011 Oct;60(4):834-41. doi:
10.1016/j.eururo.2011.07.036. Epub 2011 Jul 30. PMID: 21820797.
48: Gandaglia G, Suardi N, Gallina A, CAPITANIO U, Abdollah F, Salonia A, Nava
L, Colombo R, Guazzoni G, Rigatti P, Montorsi F, Briganti A. Preoperative
erectile function represents a significant predictor of postoperative urinary
continence recovery in patients treated with bilateral nerve sparing radical
prostatectomy. J Urol. 2012 Feb;187(2):569-74. doi: 10.1016/j.juro.2011.10.034.
Epub 2011 Dec 15. PMID: 22177170.
49: Dell'Oglio P, Abou-Haidar H, Leyh-Bannurah SR, Tian Z, Larcher A, Gandaglia
G, Fossati N, Shariat SF, CAPITANIO U, Briganti A, Montorsi F, Graefen M, Saad
F, Karakiewicz PI. Assessment of the Rate of Adherence to International
Guidelines for Androgen Deprivation Therapy with External-beam Radiation
Therapy: A Population-based Study. Eur Urol. 2016 Sep;70(3):429-35. doi:
10.1016/j.eururo.2016.02.057. Epub 2016 Mar 4. PMID: 26951945.
50: Larcher A, Sun M, Dell'Oglio P, Trudeau V, Boehm K, Schiffmann J, Tian Z,
Fossati N, CAPITANIO U, Briganti A, Montorsi F, Karakiewicz P. Mortality,
morbidity and healthcare expenditures after local tumour ablation or partial
nephrectomy for T1A kidney cancer. Eur J Surg Oncol. 2017 Apr;43(4):815-822.
doi: 10.1016/j.ejso.2016.08.023. Epub 2016 Sep 17. PMID: 27692535.
51: Suardi N, Gallina A, Lista G, Gandaglia G, Abdollah F, CAPITANIO U,
Dell'Oglio P, Nini A, Salonia A, Montorsi F, Briganti A. Impact of adjuvant
radiation therapy on urinary continence recovery after radical prostatectomy.
Eur Urol. 2014 Mar;65(3):546-51. doi: 10.1016/j.eururo.2013.01.027. Epub 2013
Feb 4. PMID: 23415377.
52: CAPITANIO U, Briganti A, Suardi N, Gallina A, Salonia A, Freschi M, Rigatti
P, Montorsi F. When should we expect no residual tumor (pT0) once we submit
incidental T1a-b prostate cancers to radical prostatectomy? Int J Urol. 2011
Feb;18(2):148-53. doi: 10.1111/j.1442-2042.2010.02689.x. Epub 2010 Dec 30. PMID:
21198944.
53: Capogrosso P, CAPITANIO U, Vertosick EA, Ventimiglia E, Chierigo F, Oreggia
D, Moretti D, Briganti A, Vickers AJ, Montorsi F, Salonia A. Temporal Trend in
Incidental Prostate Cancer Detection at Surgery for Benign Prostatic
Hyperplasia. Urology. 2018 Dec;122:152-157. doi: 10.1016/j.urology.2018.07.028.
Epub 2018 Aug 20. PMID: 30138683; PMCID: PMC6724539.
54: Sharma G, Shah M, Ahluwalia P, Dasgupta P, Challacombe BJ, Bhandari M,
Ahlawat R, Rawal S, Buffi NM, Sivaraman A, Porter JR, Rogers C, Mottrie A, Abaza
R, Rha KH, Moon D, Yuvaraja TB, Parekh DJ, CAPITANIO U, Maes KK, Porpiglia F,
Turkeri L, Gautam G. Perioperative outcomes following robot-assisted partial
nephrectomy in elderly patients. World J Urol. 2022 Nov;40(11):2789-2798. doi:
10.1007/s00345-022-04171-4. Epub 2022 Oct 6. PMID: 36203102.
55: Sorce G, Hoeh B, Hohenhorst L, Panunzio A, Tappero S, Nimer N, Tian Z,
Larcher A, CAPITANIO U, Tilki D, Terrone C, Chun FKH, Antonelli A, Saad F,
Shariat SF, Montorsi F, Briganti A, Karakiewicz PI. Contemporary vs historical
survival rates in metastatic clear cell renal carcinoma according to
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